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Genetic Architecture of Hypertrophic and Dilated Cardiomyopathies and Arrhythmogenic Right Ventricular Dysplasia
| HCM | DCM | ARVD | |
|---|---|---|---|
| Prevalence | 1/500 | 1/2500 | 1/1000–1/5000 |
| No. known causal genes | 12 | 20 | 7 |
| No. known variants | >400 | >50 | >70 |
| Familiality | 50% | 35% | 30–50% |
| Predominant patterns of inheritance | Autosomal dominant | Autosomal dominant, Autosomal recessive, X-linked | Autosomal dominant, Autosomal recessive |
| Potential Preventive Treatment | AICD | ACE-I, beta-blocker, AICD | Avoidance of exercise, AICD |
