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. Author manuscript; available in PMC: 2010 May 23.
Published in final edited form as: Biochim Biophys Acta. 2008 Sep 18;1795(1):25–36. doi: 10.1016/j.bbcan.2008.09.001

Figure 1. BAR family of adapter proteins.

Figure 1

The primary structure of amphiphysin-like proteins and other selected ubiquitous and tissue-specific members of the BAR adapter family with relevance to cancer are presented. The organization and nomenclature of the various splice isoforms of Bin1 discussed in the text are noted. Exons 6, 10, 13, and 12A-D as defined by Wechsler-Reya et al. are alternately spliced [137]. While alternate splice isoforms for the other genes are known there has been generally little if any functional analysis reported, in contrast to Bin1 isoforms of Bin1. SH3, Src homology 3 domain; MBD, Myc binding domain; CLAP, clathrin-AP2 binding region; PH, pleckstrin homology region (PI binding); PTB, phosphotyrosine binding region; RhoGEF, Rho guanine nucleotide exchange function; RhoGAP, Rho guanine nucleotide activating protein function; pX, phox homology region (PI binding).

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