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. Author manuscript; available in PMC: 2010 May 24.
Published in final edited form as: Cancer Cell. 2009 Mar 3;15(3):220–231. doi: 10.1016/j.ccr.2009.01.027

Figure 8. Adaptive-Evasive Responses by Tumors to Antiangiogenic Therapies.

Figure 8

Schematic summary of adaptive responses to VEGF/VEGFR inhibitors (and likely other angiogenesis inhibitors) that elicit “evasive resistance.” Tumors respond to VEGF/VEGFR pathway inhibition with tumor stasis or regression and a loss of blood vessels, but mechanisms of evasive resistance to the antiangiogenic treatment are then induced that can variously enable revascularization via alternative proangiogenic signals, increased local invasiveness, and/or enhanced distant metastasis.