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. 2010 Mar 23;160(2):233–245. doi: 10.1111/j.1476-5381.2010.00663.x

Figure 1.

Figure 1

Effect of MDMA on mitochondrial complex I and aconitase activities and superoxide (O2-) production. (A) Mitochondrial complex I in the striatum of mice killed 1, 3, 6, 12 and 24 h after MDMA (10, 20, 30 mg·kg−1 i.p. every 2 h). (B) Representative photomicrographs showing fluorescent ethidium signals 3 h after saline or MDMA. Note that MDMA treatment resulted in a significant increased in oxidized hydroethidine signals compared with saline-treated mice. (C) Effect of MDMA on aconitase activity in mice killed 1, 3 and 6 h after MDMA. The results shown as mean ± SEM (n= 10; A and C). Differences from saline: *P < 0.05. MDMA, 3,4-methylenedioxymethamphetamine.