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. 2010 Mar 23;160(2):233–245. doi: 10.1111/j.1476-5381.2010.00663.x

Figure 2.

Figure 2

Effect of the NOS inhibitor L-NNA alone or in combination with D- or L-arginine on MDMA-induced striatal dopamine loss. L-NNA (10 mg·kg−1 i.p.) or saline were administered 30 min before MDMA (10, 20, 30 mg·kg−1 i.p. every 2 h), and D- or L-arginine (300 mg·kg−1 i.p.) were given 5 min before L-NNA or saline. Mice were killed 7 days later. L-arginine but not D-arginine reversed the protection afforded by L-NNA against MDMA-induced dopamine depletions. Discontinous line (----) represents dopamine levels in saline-treated mice. Results shown as means ± SEM (n= 8–12). *P < 0.05 different from saline; †P < 0.05 different from MDMA-treated mice. L-NNA, NG-nitro-L-arginine; MDMA, 3,4-methylenedioxymethamphetamine; NOS, nitric oxide synthase.