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. 2010 Mar 23;160(2):233–245. doi: 10.1111/j.1476-5381.2010.00663.x

Figure 4.

Figure 4

Effect of BSO on MDMA induced-toxicity. BSO (3 mmol·kg−1 i.p.) was given 24 h before the fourth injection of LA (4 × 100 mg·kg−1 i.p. 12 h apart). (A) Striatal GSH levels 24 h after BSO given alone or in combination with LA. Results shown as means ± SEM (n= 8–10). *P < 0.05 versus saline; #P < 0.05 versus BSO-treated animals. (B) Striatal dopamine, DOPAC and HVA levels of mice 7 days after administration of BSO or LA in combination with MDMA. Discontinous line (----) shows dopamine, DOPAC and HVA levels of saline-treated mice. Results shown as means ± SEM (n= 8–12). *P < 0.05, different from saline; †P < 0.05, different from MDMA-treated mice; #P < 0.05, different from BSO + MDMA treated animals. One-way anova followed by Newman–Keuls test. BSO, L-buthionine-(S,R)-sulfoximine; DOPAC, 3,4-dihydroxyphenylacetic acid; GSH, glutathione; LA, α-lipoic acid; MDMA, 3,4-methylenedioxymethamphetamine.