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. 2010 Mar 23;160(2):233–245. doi: 10.1111/j.1476-5381.2010.00663.x

Figure 5.

Figure 5

Effect of MPTP on MDMA-induced toxicity. (A) Striatal dopamine levels 7 days after the administration of MDMA (3 × 10 mg·kg−1 i.p. every 2 h) alone or in combination with MPTP (3 × 10 mg·kg−1 i.p. every 2 h). (B) mitochondrial complex I activity 3 h after the same drug treatments shown in panel A. (C) Striatal dopamine levels 7 days after the administration of MDMA (10, 20, 30 mg·kg−1 i.p. every 2 h) alone or in combination with MPTP (3 × 10 mg·kg−1 i.p. every 2 h). (D) mitochondrial complex I activity 3 h after the same drug treatments shown in panel C. Results shown as means ± SEM (n= 8–12). *P < 0.05 versus saline-treated mice. One-way anova followed by Newman–Keuls test. MDMA, 3,4-methylenedioxymethamphetamine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.