Table 1.

Effect of MDMA (10, 20, 30 mg·kg^-1 i.p. every 2 h) on the activities of mitochondrial complexes II, II/III, IV and citrate synthase at various time points

	Complex II	Complex II/III	Complex IV	Citrate synthase
Control	13.28 ± 0.83	17.05 ± 0.51	6.01 ± 1.01	45.72 ± 1.19
1 h	12.04 ± 0.61	16.97 ± 0.62	5.30 ± 0.58	43.93 ± 1.05
3 h	11.67 ± 0.69	17.22 ± 0.49	6.33 ± 0.54	44.99 ± 1.05
6 h	12.09 ± 0.76	17.15 ± 0.28	5.24 ± 0.51	45.41 ± 1.31
12 h	12.49 ± 0.83	17.08 ± 0.54	5.03 ± 0.57	43.18 ± 1.68
24 h	12.34 ± 0.82	16.75 ± 0.97	6.67 ± 0.56	45.73 ± 1.52

Results shown as mean ± SEM, n= 10, in DCPIP nmol·min⁻¹·mg⁻¹ tissue (complex II), cytochrome c nmol·min⁻¹·mg⁻¹ tissue (complex II/III), cytochrome c µmol·min⁻¹·mg⁻¹ tissue (complex IV) and DTNB nmol·min⁻¹·mg⁻¹ tissue (citrate synthase).

One-way anova revealed no significant differences between control and MDMA treatment at any time point.

DCPIP, 2,6-dichlorophenolindo phenol; DTNB, 5,5′-dithiobis-(2-nitrobenzoic acid); MDMA, 3,4-methylenedioxymethamphetamine.