Figure 1.

Effect of β₂-adrenoceptor agonists and cAMP-elevating agents on the release of IL-6 and IL-8. BEAS-2B cells were either left untreated or were incubated with: (A) salbutamol (1 µM), salmeterol (0.1 µM) or formoterol (0.01 µM), or (B) forskolin (10 µM) or PGE₂ (1 µM) for 1 h prior to either being left not stimulated (NS) or stimulated with IL-1β (1 ng·mL⁻¹), or IL-1β (1 ng·mL⁻¹) and histamine (100 µM) (I + H). Cells were harvested after 6 h, and the supernatants were analysed by elisa for IL-6 and IL-8 release. Data (n= 4–6), expressed as pg·mL⁻¹, are plotted as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 versus IL-1β, ##P < 0.01, ###P < 0.001 versus I + H.