Table 2.
Primary outcome (PDQ-39)
|
Baseline |
1 year |
Change between baseline and 1 year |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Surgery (n=178) | Medical therapy (n=178) | Surgery (n=162) | Medical therapy (n=153) | Difference in means at 1 year (95% CI) | p | Surgery (n=160) | Medical therapy (n=150) | Difference in the mean change (95% CI) | p | |
| Summary index | 37·5 (14·6) | 38·7 (13·7) | 32·5 (15·8) | 38·1 (13·5) | −5·6 (−8·9 to −2·4) | 0·0008 | −5·0 (14·1) | −0·3 (11·1) | −4·7 (−7·6 to −1·8) | 0·001 |
| Mobility | 56·3 (22·5) | 60·1 (22·4) | 48·1 (25·2) | 60·2 (23·6) | −12·0 (−17·5 to −6·6) | <0·0001 | −8·2 (24·8) | 0·7 (18·9) | −8·9 (−13·8 to −4·0) | 0·0004 |
| Activities of daily living | 49·6 (21·4) | 51·4 (20·4) | 37·0 (21·6) | 51·0 (21·1) | −14·0 (−18·7 to −9·3) | <0·0001 | −12·3 (23·6) | 0·1 (20·3) | −12·4 (−17·3 to −7·5) | <0·0001 |
| Emotional wellbeing | 31·3 (19·7) | 31·0 (19·5) | 27·9 (21·1) | 28·6 (18·8) | −0·7 (−5·1 to 3·8) | 0·77 | −3·3 (20·9) | −1·2 (16·2) | −2·1 (−6·3 to 2·1) | 0·33 |
| Stigma | 33·2 (25·2) | 37·2 (26·0) | 25·5 (24·2) | 35·0 (24·6) | −9·5 (−14·9 to −4·1) | 0·0006 | −8·1 (24·4) | −3·0 (21·9) | −5·2 (−10·4 to 0·03) | 0·05 |
| Social support | 18·8 (19·0) | 16·6 (20·9) | 19·2 (20·5) | 16·8 (19·3) | 2·4 (−2·1 to 6·8) | 0·30 | 0·6 (18·4) | 0·5 (19·3) | 0·1 (−4·1 to 4·4) | 0·95 |
| Cognition | 30·4 (19·7) | 29·6 (20·5) | 28·6 (21·3) | 30·0 (19·4) | −1·4 (−5·9 to 3·1) | 0·54 | −1·7 (19·7) | 1·4 (19·2) | −3·0 (−7·4 to 1·3) | 0·17 |
| Communication | 31·9 (23·1) | 31·7 (23·1) | 34·3 (23·0) | 33·0 (21·0) | 1·3 (−3·6 to 6·2) | 0·61 | 2·9 (22·3) | 1·6 (18·0) | 1·4 (−3·2 to 5·9) | 0·55 |
| Bodily discomfort | 48·9 (23·1) | 52·1 (23·8) | 39·2 (23·7) | 50·0 (23·0) | −10·9 (−16·1 to −5·7) | <0·0001 | −9·8 (23·1) | −2·4 (22·6) | −7·5 (−12·6 to −2·4) | 0·004 |
Data are mean (SD). The PDQ-39 range is 0–100; the higher the score, the worse the self-reported quality of life; negative change=improvement. Ten baseline forms and 51 1-year forms were not returned. Five patients returned 1-year PDQ-39 forms, but did not return baseline PDQ-39 forms, so we were unable to calculate a change from baseline for these patients. Missing values in PDQ-39 domain scores were imputed using the expectation maximisation algorithm. PDQ-39=39-item Parkinson's disease questionnaire.