TABLE 2.
Additive | AS-1 | AS-3 | Toxic dose* |
---|---|---|---|
Sodium chloride | 42 | 7.5 | 137 mg/kg/day |
Dextrose | 129 | 23 | 240 mg/kg/hr |
Adenine | 0.6 | 0.6 | 15 mg/kg/dose |
Citrate | 9.8 | 12.6 | 180 mg/kg/hr |
Phosphate | 2.0 | 5.6 | >60 mg/kg/day |
Mannitol | 33 | 0 | 360 mg/kg/day |
The accuracy of toxic dose is difficult to predict because RBC infusion rates are slow, allowing metabolism and distribution of additives into extravascular sites. In addition, dextrose, adenine, and phosphate enter RBCs and are somewhat sequestered and not immediately “available” in the extracellular solution. Potential toxic doses from Luban et al.24