| Acetaminophen, NSAIDs |
Mild rash, arthritis |
|
| Oral steroids (1-2 mg/Kg) |
Severe rash, cutaneous edema, severe colicky abdominal pain, scrotal and testicular involvement |
These cannot prevent development of systemic involvement but can be helpful for symptomatic treatment. These decrease the duration of symptoms when compared to placebo group |
| IV steroids (1-2 mg/Kg) |
Same as oral steroids, should be given if patient is not able to tolerate oral medications |
Same as oral steroids |
| High-dose IV pulse steroids |
Nephrotic range proteinuria |
Decreases ESRD progression (in some case series and reports) |
| High-dose IV pulse steroids plus immunosuppression |
Rapidly progressive glomerulonephritis (RPGN), hemorrhagic involvement of lungs, brain |
Grade D recommendation |
| Plasmapheresis and/or IV immunoglobulin therapy |
Refractory HSP to combination therapy (steroids and immunosuppression), massive hemorrhage in gastrointestinal or other organs |
Grade D recommendation, but evidence is growing with multiple case series and reports. This is used as the last resort to treat refractory HSP. |
