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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Int J Androl. 2010 Apr;33(2):443–462. doi: 10.1111/j.1365-2605.2009.01049.x

Figure 5.

Figure 5

Summary of the observed and predicted effects in our new multi-component mixture study with ten chemicals (four pesticides and six phthalates) on reproductive tract organ weights measured in adult F1 males. Individual chemical data that went into models can be found in Rider et al. 2008. The ED50s as % of the top dose (100%) are shown for the observed and predicted effects of the mixture on F1 male rat seminal vesicle (Fig 5A), epididymal (Fig 5B), ventral prostate (Fig 5C) and LABC (Fig 5D) weights. Predicted ED50 values with shading fall outside of the 95% confidence limits surrounding the ED50 calculated from the observed data. The reductions in seminal vesicle, ventral prostate, epididymal and LABC weights were all more accurately predicted by dose addition (DA) than by either integrated addition (IA) or response addition (RA) models. The DA model accurately predicted all the reductions except for the reduction in ventral prostate weight, where it slightly under-predicted the magnitude of the effect. However, it was still clearly the “best” model as compared to IA or RA predictions. Values on the figures are means and standard errors of observed responses and predicted responses.