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. 2010 Jan 15;38(9):2891–2903. doi: 10.1093/nar/gkp1250

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© The Author(s) 2010. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — ITPA-deficient phenotypes are reversed during immortalization. (A) Immortalized Itpa^−/– MEFs (triangle) showed the same proliferation rate as did immortalized Itpa^+/+ (circle) and Itpa^+/− (square) MEFs. Error bars represent the SD (n = 3 independent isolates). (B) The frequency of chromosomal abnormalities was decreased in immortalized Itpa^−/– MEFs to the levels seen in immortalized Itpa^+/+ MEFs. Data are shown as the mean ± SD (n = 3 independent isolates).