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. 2009 Aug 26;29(34):10588–10599. doi: 10.1523/JNEUROSCI.2323-09.2009

Figure 3.

Figure 3.

Electrophysiological evidence for reduced glutamate and potassium buffering during epileptogenesis. a, Single NMDA-mediated EPSCs in control slices and 24 h following albumin treatment in vivo in ACSF (gray) and following DHK (black) application. Inset, Mean EPSC amplitude in ACSF. b, NMDA-mediated EPSCs during train stimulation at 50 Hz in control and treated animals. c, Mean evoked NMDA-mediated EPSC at different stimulation frequencies. d, [K+]o levels in control and treated slices during 20 Hz stimulation. e, Mean [K+]o levels during extracellular stimulation at 2–100 Hz (right). #p < 0.03, *p < 0.001 (n = 6 albumin-treated cells, 5 animals, n = 9 control cells, 7 animals).