Table 3.
Comparison of medication use by age at SLE diagnosis in the Lupus Outcomes Study (n = 885)*
| Ever prescribed† |
Currently prescribed |
|||||
|---|---|---|---|---|---|---|
| Medications | Childhood onset |
Adult onset |
P | Childhooc onset |
Adult onset |
P |
| Antiinflammatories | ||||||
| Nonsteroidals | 81.8 | 88.1 | 0.09 | 45.5 | 48.7 | 0.57 |
| COX-2 inhibitors | 23.0 | 49.9 | < 0.001 | 10.3 | 16.9 | 0.12 |
| Hydroxychloroquine | 87.6 | 83.8 | 0.35 | 53.9 | 51.3 | 0.64 |
| Steroids | ||||||
| Prednisone | 100.0 | 89.3 | 0.001 | 67.8 | 42.7 | < 0.001 |
| Methylprednisolone (IV) | 48.8 | 38.4 | 0.064 | 14.3 | 7.1 | 0.02 |
| Immunosuppressives | ||||||
| Mycophenolate mofetil | 28.1 | 13.0 | < 0.001 | 13.5 | 7.5 | 0.052 |
| Cyclophosphamide (oral) | 3.5 | 7.5 | 0.16 | 0.0 | 0.13 | 0.74 |
| Cyclophosphamide (IV) | 30.7 | 14.1 | < 0.001 | 6.8 | 1.7 | 0.002 |
| Azathioprine | 33.7 | 28.4 | 0.29 | 5.6 | 9.3 | 0.25 |
| Cyclosporine | 18.6 | 9.9 | 0.014 | 2.3 | 2.7 | 0.81 |
| Methotrexate (oral) | 20.2 | 23.8 | 0.44 | 5.6 | 8.7 | 0.32 |
| Methotrexate (injectable) | 6.7 | 7.1 | 0.89 | 1.1 | 1.8 | 0.65 |
*
SLE = systemic lupus erythematosus; COX-2 = cyclooxygenase 2; IV= intravenous.
†
Data collected from baseline interview.