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. Author manuscript; available in PMC: 2010 May 24.
Published in final edited form as: Neuron. 2008 Jul 31;59(2):207–213. doi: 10.1016/j.neuron.2008.06.019

Figure 2. Decreased IPSCs during pregnancy.

Figure 2

a, Representative whole-cell patch clamp recordings from DGGC from wild type and Gabrd−/− mice. b, Superimposed averages reveal a decrease in the amplitudes of sIPSCs in both wild type and Gabrd−/− mice during pregnancy. Peak-scaled sIPSCs show no change in kinetics in wild type and Gabrd−/− mice. The decreased peak amplitude can be appreciated in the cumulative probability plots of an equal number of representative sIPSCs from wild type and Gabrd−/− virgin, pregnant (d18) mice, and postpartum mice. c, The average amplitudes of sIPSCs is decreased in both pregnant wild type and Gabrd−/− mice. d, The average mIPSCs amplitude is decreased in pregnant wild type mice compared to virgin mice. There is no change in the unitary conductance of receptors, as determinde by nonstationary fluctuation analysis, between wild type pregnant and virgin mice.