Comparison of the genetic parameters of multiple compartments between patients with mild and severe recurrent disease. Panel A, the mean values of synonymous nucleotide substitutions (dS); Panel B, the mean values of non-synonymous nucleotide substitutions (dN); Panel C, the mean values of dN/dS ratios; Panel D, the mean values of nucleotide genetic distances; Panel E, the mean values of amino acid genetic distances. The Mann-Whitney U test was used to compare differences between the groups with mild and severe recurrent disease.