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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2010 Apr 24;49(1):109–116. doi: 10.1016/j.freeradbiomed.2010.04.006

Fig 1.

Fig 1

DHODH protein is expressed in premalignant and malignant human skin and prostate epithelial cells. (A) A diagrammatic depiction of DHODH in the inner mitochondrial membrane illustrating its role in mitochondrial bioenergetics and de novo pyrimidine synthesis. Please refer to the text for additional details (abbreviations: III, complex III, IV, complex IV; FMN, flavin mononucleotide). An immunoblot analysis of DHODH expression for the premalignant HaCaT and malignant COLO 16, SCC-13, SRB-1, and SRB-12 cutaneous keratinocytes (B), and the premalignant PWR-1E and malignant DU-145, LNCaP, and PC-3 prostate epithelial cells (C).