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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2010 Apr 24;49(1):109–116. doi: 10.1016/j.freeradbiomed.2010.04.006

Figure 6.

Figure 6

Resistance to 4HPR-induced apoptosis in SW480 colon cancer cells is associated with negligible DHODH expression and 4HPR-induced ROS generation. (A) The hypoploid cells in the indicated treatments were determined by flow cytometry. *P<0.001 compared to the 24-h control and **P<0.01 compared to the respective 48- and 72-h controls. (B) An immunoblot analysis of DHODH, ND6, and COII expression for the PWR-1E, COLO 16, and SW480 cells. (C) The rates of 4HPR-induced ROS generation were assessed in the PWR-1E and SW480 cells as described in Fig. 3C. *P<0.001 compared to the PWR-1E control and **P<0.05 compared to the SW480 control.