Table 2.
SNP | Genotype | Caucasians | African Americans | ||||||
---|---|---|---|---|---|---|---|---|---|
Cases (%) (n=1,258)a | Controls (%) (n=1,241)a | Adjusted ORb (95% CI) | Ptrendc | Cases (%) (n=143)a | Controls (%) (n=80)a | Adjusted ORb (95% CI) | Ptrendc | ||
rs12461158 | GG | 692(55.4) | 651(52.4) | ref | 71(50.0) | 41(51.3) | ref | ||
AG | 476(38.1) | 506(40.7) | 0.89 (0.75–1.04) | 56(39.4) | 33(41.3) | 0.97 (0.52–1.78) | |||
AA | 81(6.5) | 85(6.8) | 0.90 (0.65–1.24) | 15(10.6) | 6(7.5) | 1.35 (0.47–3.88) | |||
AA+AG | 0.89 (0.76–1.04) | 0.18 | 1.03 (0.58–1.84) | 0.72 | |||||
rs2451996 | TT | 425(34.2) | 409(33.1) | ref | 14(9.9) | 7(8.8) | ref | ||
CT | 612(49.3) | 593(48.0) | 0.99 (0.83–1.18) | 49(34.5) | 42(52.5) | 0.46 (0.16–1.35) | |||
CC | 204(16.4) | 233(18.9) | 0.84 (0.67–1.06) | 79(55.6) | 31(38.8) | 1.16 (0.40–3.33) | |||
CC+CT | 0.95 (0.80–1.12) | 0.20 | 0.76 (0.28–2.08) | 0.09 | |||||
rs1688043 | AA | 1,089(88.0) | 1,084(88.0) | ref | 95(67.9) | 57(73.1) | ref | ||
AG | 145(11.7) | 142(11.5) | 1.01 (0.79–1.30) | 40(28.6) | 21(26.9) | -- | |||
GG | 4(0.3) | 6(0.5) | 0.66 (0.19–2.34) | 5(3.6) | 0(0.0) | -- | |||
GG+AG | 1.00 (0.78–1.27) | 0.90 | 1.23 (0.65–2.35) | ||||||
rs2305746 | GG | 1,093(88.0) | 1,093(88.1) | ref | 88(62.0) | 55(68.8) | ref | ||
AG | 145(11.7) | 141(11.4) | 1.03 (0.80–1.31) | 47(33.1) | 22(27.5) | 1.23 (0.65–2.34) | |||
AA | 4(0.3) | 7(0.6) | 0.57 (0.17–1.94) | 7(4.9) | 3(3.8) | 1.24 (0.30–5.19) | |||
AA+AG | 1.00 (0.79–1.28) | 0.88 | 1.23 (0.67–2.27) | 0.53 | |||||
rs2305747 | TT | 668(54.5) | 673(55.0) | ref | 22(15.5) | 12(15.0) | ref | ||
CT | 485(39.6) | 457(37.3) | 1.07 (0.91–1.26) | 62(43.7) | 48(60.0) | 0.64 (0.27–1.49) | |||
CC | 73(6.0) | 94(7.7) | 0.78 (0.56–1.08) | 58(40.8) | 20(25.0) | 1.49 (0.60–3.71) | |||
CC+CT | 1.02 (0.87–1.20) | 0.62 | 0.89 (0.40–2.00) | 0.15 | |||||
rs1688029 | AA | 571(47.3) | 571(47.0) | ref | 17(12.2) | 10(12.5) | ref | ||
AG | 520(43.0) | 517(42.6) | 1.00 (0.85–1.19) | 51(36.7) | 39(48.8) | 0.64 (0.25–1.65) | |||
GG | 117(9.7) | 126(10.4) | 0.93 (0.70–1.23) | 71(51.1) | 31(38.8) | 1.26 (0.49–3.26) | |||
GG+AG | 0.99 (0.84–1.16) | 0.72 | 0.91 (0.37–2.23) | 0.19 |
Variable numbers of cases and controls reflect failed genotyping.
Adjusted for age. If there are no case or control homozygote carriers of the less common allele, then only the dominant model risk estimate is shown.
Analysis for linear trend according to the number of variant alleles. If there are homozygote carriers of the less common allele this analysis is omitted.