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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: Prostate. 2010 Jun 15;70(9):1020–1035. doi: 10.1002/pros.21137

Table 2.

Prostate cancer risk associated with SNPs in cav-1 and cav-2, by race

Genotype Cases
(n=1,457)a 		Controls
(n=1,351)a 		ORb 95% CI Pc
n (%) n (%)
Caucasians
Cav-1
rs4236601, chr7:115949965
   GG 604 (49.0) 637 (52.0) 1.00 Reference
   GA 537 (21.8) 500 (40.8) 1.13 0.96 1.34
   AA 92 (3.7) 89 (7.3) 1.10 0.80 1.50 0.32
   GA or AA 629 (51.0) 589 (48.0) 1.13 0.96 1.32 0.13
rs926198, chr7:115954444
   TT 568 (45.3) 538 (43.9) 1.00 Reference
   CT 537 (42.9) 539 (43.9) 0.94 0.80 1.12
   CC 148 (11.8) 150 (12.2) 0.94 0.73 1.22 0.77
   CT or CC 685 (54.7) 689 (56.2) 0.94 0.80 1.11 0.47
rs10256914, chr7:115962947
   TT 676 (53.2) 684 (55.0) 1.00 Reference
   TC 505 (39.8) 474 (38.1) 1.08 0.92 1.27
   CC 89 (7.0) 85 (6.8) 1.06 0.77 1.46 0.65
   TC or CC 594 (46.8) 559 (45.0) 1.08 0.92 1.26 0.35
rs3807986, chr7:115965061
   AA 729 (58.0) 720 (57.9) 1.00 Reference
   GA 455 (36.2) 457 (36.8) 0.98 0.83 1.16
   GG 72 (5.7) 66 (5.3) 1.09 0.77 1.55 0.85
   GA or GG 527 (42.0) 523 (42.1) 1.00 0.85 1.17 0.95
rs959173, chr7:115969290
   TT 893 (70.5) 886 (71.3) 1.00 Reference
   CT 335 (26.4) 328 (26.4) 1.02 0.85 1.22
   CC 39 (3.1) 29 (2.3) 1.35 0.82 2.20 0.49
   CT or CC 374 (29.5) 357 (28.7) 1.04 0.88 1.24 0.63
rs3807989, chr7:115973477
   GG 436 (34.5) 421 (33.9) 1.00 Reference
   GA 597 (47.2) 626 (50.4) 0.92 0.77 1.10
   AA 232 (18.3) 196 (15.8) 1.16 0.92 1.46 0.12
   GA or AA 829 (65.5) 822 (66.1) 0.98 0.83 1.15 0.77
rs3801995, chr7:115977833
   CC 705 (55.7) 690 (55.6) 1.00 Reference
   CT 474 (37.4) 479 (38.6) 0.97 0.82 1.14
   TT 87 (6.9) 72 (5.8) 1.20 0.86 1.67 0.46
   CT or TT 561 (44.3) 551 (44.4) 1.00 0.85 1.17 0.98
rs1049314, chr7:115986931
   CC 847 (67.2) 863 (69.3) 1.00 Reference
   CA 378 (30.0) 352 (28.3) 1.10 0.92 1.31
   AA 36 (2.9) 30 (2.4) 1.24 0.75 2.03 0.44
   CA or AA 414 (32.8) 382 (30.7) 1.11 0.94 1.31 0.23
rs9920, chr7:115987328
   TT 993 (78.3) 1,031 (83.0) 1.00 Reference
   CT 262 (20.7) 204 (16.4) 1.35 1.10 1.65
   CC 14 (1.1) 7 (0.6) 2.09 0.84 5.22 0.006
   CT or CC 276 (21.8) 211 (17.0) 1.37 1.12 1.68 0.002
rs1049334, chr7:115987616
   GG 1,077 (84.9) 1,033 (83.2) 1.00 Reference
   GA 186 (14.7) 203 (16.3) 0.88 0.71 1.09
   AA 6 (0.5) 6 (0.5) 0.96 0.31 3.00 0.50
   GA or AA 192 (15.1) 209 (16.8) 0.88 0.71 1.09 0.24
rs1049337, chr7:115987823
   CC 675 (53.7) 625 (50.4) 1.00 Reference
   CT 489 (38.9) 514 (41.5) 0.87 0.74 1.03
   TT 93 (7.4) 100 (8.1) 0.86 0.63 1.16 0.23
   CT or TT 582 (46.3) 614 (49.6) 0.87 0.74 1.02 0.09
Cav-2
rs17138767, chr7:115924913
   AA 1,076 (85.3) 1,041 (84.0) 1.00 Reference
   GA 180 (14.3) 194 (15.7) 0.89 0.72 1.11
   GG 5 (0.4) 5 (0.4) 0.99 0.28 3.42 0.59
   GA or GG 185 (14.7) 199 (16.1) 0.89 0.72 1.11 0.31
rs4730742, chr7:115925128
   TT 843 (67.0) 822 (66.2) 1.00 Reference
   GT 381 (30.3) 379 (30.5) 0.98 0.82 1.16
   GG 35 (2.8) 40 (3.2) 0.86 0.54 1.37 0.80
   GT or GG 416 (33.0) 419 (33.8) 0.97 0.82 1.14 0.68
rs8940, chr7:115933310
   CC 853 (67.4) 816 (65.7) 1.00 Reference
   CG 377 (29.8) 379 (30.5) 0.95 0.80 1.13
   GG 35 (2.8) 47 (3.8) 0.72 0.46 1.13 0.32
   CG or GG 412 (32.6) 426 (34.3) 0.92 0.78 1.09 0.35
rs4727833, chr7:115935144
   CC 352 (27.8) 313 (25.2) 1.00 Reference
   GC 617 (48.7) 640 (51.5) 0.85 0.70 1.03
   GG 298 (23.5) 290 (23.3) 0.91 0.73 1.13 0.24
   GC or GG 915 (72.2) 930 (74.8) 0.87 0.73 1.04 0.12
rs1052990, chr7:115935606
   TT 517 (40.7) 508 (41.0) 1.00 Reference
   GT 591 (46.6) 590 (47.6) 0.98 0.83 1.16
   GG 161 (12.7) 142 (11.5) 1.12 0.87 1.45 0.59
   GT or GG 752 (59.3) 732 (59.0) 1.01 0.86 1.18 0.92
rs6466578, chr7:115938105
   TT 897 (71.0) 879 (70.8) 1.00 Reference
   CT 330 (26.1) 338 (27.2) 0.96 0.81 1.15
   CC 37 (2.9) 25 (2.0) 1.47 0.88 2.47 0.29
   CT or CC 367 (29.0) 363 (29.2) 1.00 0.84 1.19 0.97
rs10262524, chr7:115938188
   CC 639 (50.3) 658 (52.9) 1.00 Reference
   CA 538 (52.9) 495 (42.4) 1.12 0.95 1.32
   AA 93 (7.3) 90 (7.2) 1.07 0.79 1.46 0.38
   CA or AA 631 (49.7) 585 (47.1) 1.11 0.95 1.30 0.18
African-Americans
Cav-1
rs4236601, chr7:115949965
   GG 59 (41.0) 32 (40.0) 1.00 Reference
   GA 64 (44.4) 35 (43.8) 1.02 0.54 1.93
   AA 21 (14.6) 13 (16.3) 0.91 0.39 2.16 0.97
   GA or AA 85 (59.0) 48 (60.0) 0.99 0.55 1.79 0.98
rs926198, chr7:115954444
   TT 33 (22.8) 18 (22.5) 1.00 Reference
   CT 81 (55.9) 41 (51.3) 1.27 0.61 2.66
   CC 31 (21.4) 21 (26.3) 0.78 0.34 1.81 0.41
   CT or CC 112 (77.2) 62 (77.5) 1.08 0.54 2.16 0.83
rs10256914, chr7:115962947
   TT 93 (64.1) 51 (63.8) 1.00 Reference
   TC 40 (27.6) 25 (31.3) 0.96 0.50 1.83
   CC 12 (8.3) 4 (5.0) 1.88 0.55 6.42 0.58
   TC or CC 52 (35.9) 29 (36.3) 1.09 0.59 1.99 0.79
rs3807986, chr7:115965061
   AA 30 (20.8) 14 (17.5) 1.00 Reference
   GA 62 (43.1) 40 (50.0) 0.79 0.36 1.76
   GG 52 (36.1) 26 (32.5) 1.00 0.43 2.31 0.73
   GA or GG 114 (79.2) 66 (82.5) 0.87 0.41 1.85 0.72
rs959173, chr7:115969290
   TT 52 (35.9) 31 (38.8) 1.00 Reference
   CT 68 (46.9) 38 (47.5) 0.93 0.49 1.76
   CC 25 (17.2) 11 (13.8) 1.32 0.55 3.17 0.73
   CT or CC 93 (64.1) 49 (61.3) 1.02 0.56 1.86 0.95
rs3807989, chr7:115973477
   GG 14 (9.7) 6 (7.5) 1.00 Reference
   GA 64 (44.1) 39 (48.8) 0.83 0.28 2.51
   AA 67 (46.2) 35 (43.8) 1.01 0.33 3.08 0.81
   GA or AA 131 (90.3) 74 (92.5) 0.91 0.32 2.65 0.87
rs3801995, chr7:115977833
   CC 59 (40.7) 28 (35.0) 1.00 Reference
   CT 63 (43.5) 40 (50.0) 0.86 0.45 1.64
   TT 23 (15.9) 12 (15.0) 1.17 0.49 2.82 0.76
   CT or TT 86 (59.3) 52 (65.0) 0.93 0.51 1.71 0.83
rs1049314, chr7:115986931
   CC 73 (50.7) 38 (48.1) 1.00 Reference
   CA 56 (38.9) 36 (46.6) 0.74 0.40 1.38
   AA 15 (10.4) 5 (6.3) 1.63 0.53 5.03 0.35
   CA or AA 71 (49.3) 41 (51.9) 0.85 0.48 1.53 0.59
rs9920, chr7:115987328
   TT 142 (97.9) 77 (96.3) 1.00 Reference
   CT 3 (2.1) 3 (3.8) 0.46 0.08 2.60
   CC 0 (0.0) 0 (0.0) -- -- -- 0.38
   CT or CC 3 (2.1) 3 (3.8) 0.46 0.08 2.60 0.38
rs1049334, chr7:115987616
   GG 124 (85.5) 62 (77.5) 1.00 Reference
   GA 21 (14.5) 18 (22.5) 0.74 0.35 1.55
   AA 0 (0.0) 0 (0.0) -- -- -- 0.42
   GA or AA 21 (14.5) 18 (22.5) 0.74 0.35 1.55 0.42
rs1049337, chr7:115987823
   CC 123 (85.4) 66 (82.5) 1.00 Reference
   CT 21 (14.6) 14 (17.5) 0.77 0.35 1.68
   TT 0 (0.0) 0 (0.0) -- -- -- 0.50
   CT or TT 21 (14.6) 14 (17.5) 0.77 0.35 1.68 0.50
Cav-2
rs17138767, chr7:115924913
   AA 136 (94.4) 72 (91.1) 1.00 Reference
   GA 8 (5.6) 7 (8.9) 0.74 0.25 2.25
   GG 0 (0.0) 0 (0.0) -- -- -- 0.60
   GA or GG 8 (5.6) 7 (8.9) 0.74 0.25 2.25 0.60
rs4730742, chr7:115925128
   TT 106 (73.6) 60 (75.0) 1.00 Reference
   GT 36 (25.0) 18 (22.5) 1.41 0.71 2.81
   GG 2 (1.4) 2 (2.5) 0.39 0.05 3.02 0.39
   GT or GG 38 (26.4) 20 (25.0) 1.28 0.66 2.49 0.46
rs8940, chr7:115933310
   CC 97 (66.9) 52 (65.0) 1.00 Reference
   CG 43 (29.7) 24 (30.0) 1.10 0.58 2.08
   GG 5 (3.5) 4 (5.0) 0.58 0.14 2.41 0.70
   CG or GG 48 (33.1) 28 (35.0) 1.01 0.55 1.86 0.97
rs4727833, chr7:115935144
   CC 51 (35.4) 32 (40.0) 1.00 Reference
   GC 74 (51.4) 38 (47.5) 1.29 0.69 2.42
   GG 19 (13.2) 10 (12.5) 1.13 0.44 2.90 0.73
   GC or GG 93 (64.6) 48 (60.0) 1.26 0.69 2.29 0.45
rs1052990, chr7:115935606
   TT 54 (37.2) 29 (36.3) 1.00 Reference
   GT 70 (48.3) 35 (43.8) 1.13 0.59 2.16
   GG 21 (14.5) 16 (20.0) 0.78 0.34 1.81 0.69
   GT or GG 91 (62.8) 51 (63.8) 1.02 0.55 1.86 0.96
rs6466578, chr7:115938105
   TT 89 (61.4) 56 (70.0) 1.00 Reference
   CT 50 (34.5) 21 (26.3) 1.52 0.80 2.89
   CC 6 (4.1) 3 (3.8) 0.83 0.18 3.90 0.42
   CT or CC 56 (38.6) 24 (30.0) 1.42 0.77 2.63 0.26
rs10262524, chr7:115938188
   CC 59 (40.7) 33 (41.3) 1.00 Reference
   CA 67 (46.2) 35 (43.8) 1.11 0.59 2.08
   AA 19 (13.1) 12 (15.0) 0.93 0.38 2.27 0.90
   CA or AA 86 (59.3) 47 (58.8) 1.07 0.59 1.92 0.83

SNP=single nucleotide polymorphism; OR=odds ratio; CI=confidence interval

a

Total number of cases and controls vary by SNP due to missing genotype data.

b

Adjusted for age at reference date.

c

The first p-value is the test for trend using the codominant model; the second p-value is for the dominant model.