Table 2.
Psychosocial measures and log CRH levels in POUCH study women
| SUB-COHORT (N=1216)a |
TERM ONLYb (N=746)a |
|||||
|---|---|---|---|---|---|---|
| N (Weighted %) | Log CRH (pg/ml)c Adjusted Mean | Log CRH (pg/ml)c Mean difference (95% CI) | N (Weighted %) | Log CRH (pg/ml)c Adjusted Mean | Log CRH (pg/ml)c Mean difference (95% CI) | |
| Depressive Symptoms and Antidepressant Meds Use | ||||||
| CES-D<16 and Meds: No (referent) | 721 (62.2) | 4.29 (0.03) | 451 (63.9) | 4.30 (0.03) | ||
| CES-D<16 and Meds: Yes | 35 (3.49) | 4.19 (0.12) | −0.10 (−0.35, 0.15) | 19 (2.95) | 4.21 (0.19) | −0.09 (−0.47, 0.29) |
| CES-D>=16 and Meds: No | 385 (27.9) | 4.04 (0.04) | −0.25 (−0.34, −0.15)d | 236 (27.2) | 4.02 (0.05) | −0.28 (−0.39, −0.16)d |
| CES-D>=16 and Meds: Yes | 69 (6.36) | 4.18 (0.13) | −0.10 (−0.37, 0.16) | 36 (5.93) | 4.09 (0.16) | −0.21 (−0.53, 0.11) |
| Perceived Stress Quartiles | ||||||
| Q1 (referent) | 296 (27.4) | 4.29 (0.05) | 178 (27.1) | 4.33 (0.06) | ||
| Q2 | 312 (26.7) | 4.29 (0.04) | 0.00 (−0.13, 0.12) | 192 (26.0) | 4.29 (0.05) | −0.04 (−0.19, 0.11) |
| Q3 | 292 (22.0) | 4.19 (0.05) | −0.10 (−0.24, 0.04) | 176 (21.6) | 4.18 (0.06) | −0.15 (−0.32, 0.01) |
| Q4 | 309 (23.9) | 4.04 (0.05) | −0.25 (−0.38, −0.11)d | 195 (25.4) | 4.02 (0.06) | −0.31 (−0.47, −0.15)d |
| Anomie Quartiles | ||||||
| Q1 (referent) | 328 (31.9) | 4.34 (0.04) | 216 (34.2) | 4.33 (0.05) | ||
| Q2 | 290 (26.1) | 4.24 (0.05) | −0.10 (−0.22, 0.03) | 176 (25.7) | 4.27 (0.05) | −0.06 (−0.20, 0.08) |
| Q3 | 271 (21.1) | 4.13 (0.05) | −0.21 (−0.34, −0.08)d | 156 (19.8) | 4.10 (0.06) | −0.23 (−0.39, −0.07)d |
| Q4 | 312 (20.9) | 4.05 (0.05) | −0.29 (−0.43, −0.16)d | 189 (20.3) | 4.04 (0.06) | −0.28 (−0.44, −0.13)d |
| Hostility Quartiles | ||||||
| Q1 (referent) | 213 (21.3) | 4.36 (0.05) | 132 (21.0) | 4.36 (0.06) | ||
| Q2 | 390 (35.9) | 4.25 (0.04) | −0.11 (−0.23, 0.01) | 250 (37.6) | 4.25 (0.04) | −0.10 (−0.25, 0.04) |
| Q3 | 203 (15.8) | 4.20 (0.07) | −0.16 (−0.32, 0.01) | 118 (15.3) | 4.17 (0.08) | −0.18 (−0.38, 0.01) |
| Q4 | 406 (27.0) | 4.03 (0.04) | −0.34 (−0.47, −0.21)d | 243 (26.1) | 4.03 (0.05) | −0.33 (−0.48, −0.17)d |
| Mastery Quartiles | ||||||
| Q1 (referent) | 246 (19.4) | 4.17 (0.06) | 142 (19.0) | 4.19 (0.07) | ||
| Q2 | 256 (21.2) | 4.22 (0.05) | 0.05 (−0.10, 0.19) | 260 (35.0) | 4.21 (0.04) | 0.03 (−0.14, 0.19) |
| Q3 | 403 (33.6) | 4.18 (0.04) | 0.01 (−0.12, 0.15) | 157 (21.0) | 4.14 (0.06) | −0.05 (−0.23, 0.13) |
| Q4 | 308 (25.8) | 4.26 (0.05) | 0.09 (−0.05, 0.24) | 185 (25.0) | 4.28 (0.06) | 0.09 (−0.09, 0.27) |
| Effortful Coping Quartiles | ||||||
| Q1 (referent) | 219 (20.6) | 4.26 (0.05) | 223 (33.7) | 4.23 (0.05) | ||
| Q2 | 266 (22.8) | 4.18 (0.05) | −0.08 (−0.21, 0.06) | 174 (25.0) | 4.23 (0.05) | 0.00 (−0.15, 0.14) |
| Q3 | 347 (30.2) | 4.24 (0.05) | −0.02 (−0.16, 0.11) | 194 (24.3) | 4.17 (0.06) | −0.06 (−0.21, 0.09) |
| Q4 | 381 (26.4) | 4.15 (0.05) | −0.12 (−0.25, 0.02) | 153 (17.0) | 4.18 (0.07) | −0.05 (−0.21, 0.11) |
| Abuse | ||||||
| None (referent) | 710 (58.4) | 4.23 (0.03) | 440 (58.7) | 4.23 (0.04) | ||
| Either Childhood or Adulthood | 410 (34.4) | 4.16 (0.04) | −0.07 (−0.17, 0.02) | 256 (35.4) | 4.17 (0.04) | −0.06 (−0.18, 0.05) |
| Both Childhood and Adulthood | 91 (7.18) | 4.22 (0.11) | −0.02 (−0.25, 0.22) | 47 (5.94) | 4.19 (0.15) | −0.04 (−0.34, 0.25) |
Abbreviations: CRH = corticotropin-releasing hormone, CI= Confidence Interval, Meds = medications
a
Data missing for some psychosocial variables for 2 to 15 women
b
Excludes women with preeclampsia, gestational hypertension, chronic hypertension, and infants small for gestational age
c
Weighted for sampling scheme and adjusted for gestational week at blood sampling
d
p<0.05 compared to referent group