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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2010 Mar 17;1804(7):1443–1448. doi: 10.1016/j.bbapap.2010.03.004

Table 2.

Pair wise contacts < 5 Å of C8S ligands with residues from the sPLA2 tetramer structure.a

C8S Subunit A Subunit B Subunit C Subunit D
C8S-1 L19, N23(OD1) F63, L64, V65 W3, N23(OD1)
C8S-2 R6(NH2), H17, P18, L19, M20 L64, T70 Y69
C8S-3 L2, F5, R6, P18, L19, F22, Y28, C29, G30, C45, H48, D49, Y69
C8S-4 L19, N23(OD1), N67, Y69 R6(NH2), H17, P18, L19, M20
C8S-5 L2, F5, R6, P18, L19, Y28(O), C29, G30(O), L31, C45, D48(O), D49, Y69
C8S-6 L2, W3, L19, N23(OD1) H17
C8S-7 L2, L31, Y69, T70 R6, H17, P18, L19, M20
C8S-8 L2, F5, R6, P18, L19, Y28(O), C29, G30(O), H48(ND1), D49, Y69(OH) L64
C8S-9 L2, W3, L19, N23 F63, L64, V65
C8S-10 K121 K56, N57(O), L58, D59, C61, K62 N24, C27, L31(O), G32, N117, L118, T120
C8S-11 R6(NH2) R6, K10(NZ)
C8S-12 N24, C27, G30, L31(O), G32, L118, T120 K56(O), N57, L58, D59, C61, K62
a

Protein residue atoms in parentheses have polar interactions < 5 Å with the sulfate oxygens of C8S. The other contacts are non-polar interactions between the C8S alkyl chain and protein residue.