. Author manuscript; available in PMC: 2011 Jun 1.

Published in final edited form as: Drug Alcohol Depend. 2010 Feb 16;109(1-3):213–219. doi: 10.1016/j.drugalcdep.2010.01.006

Table 2.

Average Pain Threshold and Tolerance for Cold-Pressor at Baseline and Week 5

		Time	Group
		Mean (SE)	Gabapentin (n = 10) Mean (SE)	Placebo ( n = 14) Mean (SE)
CP Threshold (Seconds)	Trough Methadone	Baseline	7.61 (1.23)	14.23 (1.40)
		Week 5	9.90 (1.56)	13.78 (1.71)
Within-group difference in pain between Week 5 and baseline ^**			2.29 (1.58)	−0.45 (2.21)
	Peak Methadone	Baseline	7.54 (1.54)	15.82 (2.24)
		Week 5	10.49 (1.86)	12.33 (1.77)
Within-group difference in pain between Week 5 and baseline ^*			2.95 (2.41)	−3.49 (2.85)
CP Tolerance (Seconds)	Trough Methadone	Baseline	11.15 (1.04)	20.72 (1.76)
		Week 5	14.19 (1.79)	19.73 (2.42)
Within-group difference in pain between Week 5 and baseline ^***			3.04 (2.07)	−0.99 (2.99)
	Peak Methadone	Baseline	13.43 (3.02)	21.90 (2.40)
		Week 5	15.71 (1.90)	19.63 (2.96)
Within-group difference in pain between Week 5 and baseline ^*			−0.72 (3.57)	−2.27 (3.81)

Significant group difference observed at

p = 0.04,

^**

p = 0.02,

^***

p = 0.01

levels of significance using two-sample independent t-tests to test that the change scores are the same between groups versus not.