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. Author manuscript; available in PMC: 2011 Jun 15.
Published in final edited form as: Prostate. 2010 Jun 15;70(9):1002–1011. doi: 10.1002/pros.21134

Figure 2. Androgen-regulated, prostate-specific expression of PSA.

Figure 2

(A) Prostate lysates from three different mice (P719, P722, P748) showed significant PSA levels as compared to lysates from other tissues/organs or prostate from non-transgenic mice. Tissue PSA levels were determined using PSA-specific ELISA. Data shown as Mean ± SD from 3 animals. (B) Expression of the PSA transgene is androgen dependent and tissue levels of the protein decrease with time following surgical castration. PSA mice exhibit high levels of PSA expression and are similar to PSA positive controls. Following castration, prostate levels of PSA fall and at 28 days are similar to non-transgenic mouse prostates. One representative mouse is shown.