Table 2. Codon changes in the D10 RT compared to NL4-3.
Class of mutation | Codon changes relative to NL4-3 |
---|---|
nRTI resistance | M41L T215Y |
NNRTI resistance | K101E G190S |
RT polymorphisms | T27S K43N |
K102Q I142V C162S Q174K | |
Q207N R211K Q258L R277K T286A A288S V293I E298K | |
K358R A371T A376T T386I E399D | |
A400T T403S I435V D460N R461K V467I P468S Q480E L491S |
nRTI, nucleoside reverse transcriptase inhibitor
NNRTI, non-nucleoside reverse transcriptase inhibitor
RT, reverse transcriptase