Table I.

Candidate gene list for investigation of methylation in AOM induced tumors

Gene Name	Symbol	Description	Hypermethylated in human or mouse neoplasms?	Reference
Cyclin dependent kinase inhibitor 2a isoforms p16Ink4a and p19ARF	Cdkn2a p16Ink4a Cdkn2a p19ARF	Methylated in many human cancers and mouse models of lung, prostate, and pancreatic cancer	Both	[18,65–67].
Death associated protein kinase	Dapk	Hypermethylated in 81% of colorectal carcinomas and mouse lung tumors	Both	[17,68].
O6-methylguanine-DNA methyltransferase	Mgmt	Frequently methylated in colorectal cancer and in skin tumors mouse models of	Both	[14,69]
Inhibitor of DNA Binding 4	Id4	Methylated in both human and mouse leukemia	Both	[19]
Helicase-like transcription factor	Hltf	Hypermethylated in the progression of normal colonic tissue to adenoma to adenocarcinoma	Human	[35,55,70]
MutL homologue 1	Mlh1	Frequently methylated in human colon tumors, contributes to microsatellite instability	Human	[40,71,72]
Methylated in liver tumor 1	Mlt1	Hypermethylated in a SV40 T antigen transgenic mouse model that forms liver tumors.	Mouse	[73]
Tumor suppressor in lung cancer 1	Tslc-1	Hypermethylated in N-nitrosodiethylamine (DEN) induced murine hepatocelluar carcinomas	Mouse	[74]
Insulin-like Growth Factor binding protein 3	Igfbp3	Hypermethylated in a mouse carcinogen skin cancer model	Mouse	[14]
Zinc finger protein interacting with K protein 1	Zik1	Hypermethylated in gastric cancer	Human	[52]
Gap junction alpha-10 protein	Gja9	Hypermethylated in mouse tumors	Mouse	(Conerly, personal communication)
C-X-C chemokine receptor type 4	Cxcr4	Methylated in a mouse carcinogen skin cancer model	Mouse	[14]