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. 2010 Mar 3;33(6):1186–1192. doi: 10.2337/dc09-1649

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© 2010 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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A: Inverse relationship of age with free testosterone concentration in nondiabetic (non-DM, ■) lean (r = −0.53, P < 0.001), overweight (r = −0.43, P < 0.001), and obese (r = −0.28, P < 0.001) men. Thus, although age could explain ∼25% of variability (R²) in free testosterone concentrations in nonobese individuals, it accounted for a significantly lower variability (8%) in free testosterone in obese nondiabetic men (P = 0.008). DM, , diabetic men. B: Inverse relationship of age with free testosterone in lean (, r = −0.57, P < 0.001), overweight (○, r = −0.49, P < 0.001), and obese (▽, r = −0.30, P < 0.001) diabetic men. Thus, although age could explain 25–30% of variability (R²) in free testosterone concentrations in nonobese individuals, it accounted for a significantly lower variability (9%) in free testosterone in obese diabetic men (P = 0.05 compared with nonobese men). C: Relationship of free testosterone with BMI in lean (, r = 0.01, P = 0.9), overweight (○, r = −0.08, P = 0.04), and obese (▽, r = −0.10, P = 0.03) non-diabetic men. D: Relationship of free testosterone with BMI in lean (, r = 0.13, P = 0.5), overweight (○, r = 0.03, P = 0.8), and obese (▽, r = −0.17, P < 0.01) diabetic men.

A: Inverse relationship of age with free testosterone concentration in nondiabetic (non-DM, ■) lean (r = −0.53, P < 0.001), overweight (r = −0.43, P < 0.001), and obese (r = −0.28, P < 0.001) men. Thus, although age could explain ∼25% of variability (R²) in free testosterone concentrations in nonobese individuals, it accounted for a significantly lower variability (8%) in free testosterone in obese nondiabetic men (P = 0.008). DM, , diabetic men. B: Inverse relationship of age with free testosterone in lean (, r = −0.57, P < 0.001), overweight (○, r = −0.49, P < 0.001), and obese (▽, r = −0.30, P < 0.001) diabetic men. Thus, although age could explain 25–30% of variability (R²) in free testosterone concentrations in nonobese individuals, it accounted for a significantly lower variability (9%) in free testosterone in obese diabetic men (P = 0.05 compared with nonobese men). C: Relationship of free testosterone with BMI in lean (, r = 0.01, P = 0.9), overweight (○, r = −0.08, P = 0.04), and obese (▽, r = −0.10, P = 0.03) non-diabetic men. D: Relationship of free testosterone with BMI in lean (, r = 0.13, P = 0.5), overweight (○, r = 0.03, P = 0.8), and obese (▽, r = −0.17, P < 0.01) diabetic men.