Table 1.

Arguments for and against the adoption of early formula-driven haemostatic resuscitation in trauma

	Pros	Cons
Mortality	Retrospective studies suggesting a reduction in mortality from exsanguinations	Data limited by survivorship bias
		Increase in FFP and platelet use might increase the risk of acute lung injury, multiple organ failure, thrombosis, sepsis and death
Coagulopathy	Prevention and treatment of coagulopathy due to transfusion of clotting factors	Difficult to identify patients early on who will develop coagulopathy and in fact need transfusion of FFP and platelets
	Minimize crystalloid use (decrease the risk of dilution)	Uncertainty about the ideal dose of FFP in the trauma situation
Laboratory tests	No need for coagulation tests	Unnecessary exposure to AB plasma (in some countries, a higher risk of transfusion-related acute lung injury due to higher proportion of female donors)
	Avoid the delay of waiting for blood test results
Blood bank systems	More timely issuing of blood components	The waste of FFP will increase (shortage of AB plasma)
	No time needed to thaw FFP (AB plasma available at all times)	May increase the complications associated with FFP and platelet transfusion
	Decrease the need for communication between blood bank and the medical team

FFP, fresh frozen plasma.