Table 1.
Baseline characteristics at initiation of RRT
| Variable | Total | non-SIRS/sepsis | SIRS | Sepsis | P value |
|---|---|---|---|---|---|
| Number of patients (n; %) | 109 (100) | 25 (22.9) | 53 (48.6) | 31 (28.4) | |
| Age (years, median (IQR)) | 51 (40-61) | 56 (47-68) | 51 (39-60) | 48 (37-61) | 0.086 |
| Female sex (n;%) | 42 (38.5) | 5 (20.0) | 25 (47.2) | 12 (38.7) | 0.071 |
| LOS before start of RRT (median (IQR)) | 2 (1-5) | 3 (2-5) | 2 (1-7) | 2 (1-5) | 0.426 |
| APACHE II score (median (IQR)) | 34 (26-36) | 34 (27-36) | 30 (24-35) | 35 (29-40) | 0.028 |
| SOFA score (median (IQR)) | 16 (13-18) | 15 (13-17) | 14 (12-17) | 17 (16-19) | 0.011 |
| Cardiovascular variable | 4 (1-4) | 3 (1-4) | 3 (1-4) | 4 (3-4) | 0.008 |
| Respiratory variable | 2 (2-3) | 2 (2-3) | 2 (1-3) | 3 (2-4) | 0.005 |
| Coagulation variable | 1 (1-3) | 1 (1-3) | 1 (1-3) | 3 (1-3) | 0.567 |
| Liver variable | 1 (1-2) | 1 (1-2) | 2 (1-2) | 1 (1-2) | 0.858 |
| Renal variable | 3 (2-4) | 3 (2-4) | 3 (2-4) | 3 (2-4) | 0.517 |
| CNS variable | 4 (3-4) | 4 (4-4) | 4 (2-4) | 4 (4-4) | 0.009 |
| Indication for RRT | |||||
| CCR/eGFR loss >30% (n;%) | 100 (91.7) | 23 (92.0) | 49 (92.5) | 28 (90.3) | 0.942 |
| Oliguria (n;%) | 78 (71.6) | 18 (72.0) | 36 (37.9) | 24 (77.4) | 0.647 |
| Severe acidosis (n;%) | 10 (9.2) | 0 (0) | 5 (9.4) | 5 (16.5) | 0.115 |
| Hyperkalemia (n;%) | 6 (5.5) | 0 (0) | 3 (5.7) | 3 (9.7) | 0.287 |
| RIFLE class | 0.947 | ||||
| Risk (n;%) | 9 (8.3) | 2 (8.0) | 5 (9.4) | 2 (6.5) | |
| Injury (n;%) | 13 (11.9) | 2 (8.0) | 7 (13.2) | 4 (12.9) | |
| Failure (n;%) | 87 (79.8) | 21 (84.0) | 41 (77.4) | 25 (80.6) | |
| Laboratory data (median (IQR)) | |||||
| CRP (mg/L) | 138 (59-204) | 113 (60-155) | 67 (36-176) | 202 (138-303 | <0.001 |
| Creatinine (μmol/L) | 236 (185-313) | 277 (189-350) | 250 (191-348) | 203 (152-257) | 0.475 |
| Cystatin C (mg/L) | 1.82 (1.37-2.68) | 1.81 (1.47-2.4) | 1.82 (1.41-2.93) | 1.84 (1.27-2.47) | 0.676 |
| NGAL (ng/mL) | 364 (196-582) | 297 (184-490) | 315 (161-455) | 708 (365-1301) | 0.001 |
APACHE II score = Acute Physiology And Chronic Health Evaluation score; CCR = creatinine clearance; CNS = central nervous system; CRP = C reactive protein; eGFR = estimated glomerular filtration rate; IQR = interquartile range; LOS = length of stay in the intensive care unit; NGAL = neutrophil gelatinase-associated lipocalin; RIFLE = a newly developed international consensus classification for acute kidney injury, that defines three grades of severity - risk (class R), injury (class I) and failure (class F); RRT = renal replacement therapy; SOFA = Sequential Organ Failure Assessment score; SIRS = systemic inflammatory response syndrome.