Table 2.
Temporal changes observed in 11 biguanide-intoxicated patients with cardiac index and central venous oxygen saturation monitoring
| n | Day 1 | Day 2 | Day 3 | Day 4 | P | |
|---|---|---|---|---|---|---|
| pH | 11 | 7.03 (6.92-7.15) |
7.35 (7.25-7.40) |
7.44 (7.35-7.46)* |
7.46 (7.44-7.47)* |
<0.001 |
| Lactate (mM) | 11 | 17 (14-20) | 5 (2-15) | 2 (2-3)* | 1 (1-3)* | <0.001 |
| VO2 (ml/min/m2) | 9 | 67 ± 28 | 99 ± 30* | 116 ± 41* | 129 ± 42* | <0.001 |
| DO2 (ml/min/m2) | 9 | 443 ± 167 | 572 ± 152 | 491 ± 95 | 430 ± 116 | <0.01 |
| CI (L/min/m2) | 9 | 3.4 ± 1.2 | 4.4 ± 1.3 | 3.9 ± 0.8 | 3.4 ± 1.2 | 0.08 |
| C(a-v)O2 (ml O2/100 ml) |
10 | 2.0 ± 1.0 | 2.4 ± 0.8 | 2.9 ± 0.8* | 3.8 ± 1.4* | <0.001 |
| SvO2 (%) | 10 | 83 ± 8 | 80 ± 6 | 75 ± 5* | 70 ± 8* | <0.001 |
| OEI (%) | 10 | 13 (11-19) | 16 (13-21) | 23 (21-25)* | 31 (23-34)* | <0.001 |
| C(v-a)CO2 (ml CO2/100 ml) |
7 | 2.2 ± 0.8 | 2.2 ± 0.8 | 3.9 ± 1.9 | 4.7 ± 1.2* | <0.05 |
| RASS | 11 | -4 (-5--2) | -4 (-4--1) | -2 (-4-0) | -1 (-3-0) | 0.06 |
| On MV (%) | 11 | 91 | 100 | 67 | 67 | 0.12 |
| HR | 11 | 103 ± 20 | 104 ± 8 | 99 ± 16 | 97 ± 21 | 0.74 |
| SOFA | 11 | 12 ± 3 | 10 ± 1* | 9 ± 2* | 10 ± 2* | <0.001 |
| Catecholamine use (SOFA sub score) | 11 | 4 (4-4) | 4 (4-4) | 4 (4-4) | 3 (2-3)* | <0.001 |
| BT (°C) | 10 | 34.5 ± 2.2 | 36.6 ± 0.6* | 36.8 ± 0.4* | 36.7 ± 0.5* | <0.001 |
Results of repeated-measures analysis of variance and chi-squared test are reported in the right column. Data significantly different from day 1 on post-hoc comparison are indicated as *. n is the number of patients with each specific variable monitored on day 1.BT, body temperature; C(a-v)O2, arterio-venous difference in oxygen content; C(v-a)CO2, veno-arterial difference in carbon dioxide content; CI, cardiac index; DO2, systemic oxygen delivery; HR, heart rate; MV, mechanical ventilation; OEI, oxygen extraction index; RASS, Richmond Agitation Sedation Score; SOFA, Sequential Organ Failure Assessment; SvO2, central venous oxygen saturation; VO2, systemic oxygen consumption.