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. Author manuscript; available in PMC: 2010 May 25.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Jul 24;49(11):4837–4843. doi: 10.1167/iovs.08-2115

FIGURE 4.

FIGURE 4

Sensitivity of CE cells to DNA cross-linking by MMC. Goat CE cells in culture were treated with a range of MMC concentrations, and DNA cross-linking was determined using the comet assay as described in Figure 2 at three exposure times. (A) Ten-minute exposure to MMC at all concentrations induced significant DNA cross-links compared to controls. (B) Thirty-minute exposure to MMC at all concentrations (except 0.02 µg/mL, Dunnett P > 0.05) induced significant DNA cross-links compared with controls. (C) Sixty-minute exposure to MMC at all concentrations induced significant DNA cross-links compared with the control. *Significant differences from control; ANOVA P < 0.0001, Dunnett P < 0.01. Mean ± SEM.