Table 4.

Hazard ratios of developing a malignancy

	Univariate Cox regression			Multivariate analysis
	HR	95% CI	P	adjusted HR	95% CI	P
Characteristics at baseline
Age (per 10 yrs increase)	1.82	1.44 to 2.31	< 0.0001	1.71	1.35 to 2.17	< 0.0001
Male vs. female	1.61	0.98 to 2.65	0.062	1.47	0.89 to 2.43	0.13
Co-morbid conditions:
COPD	3.64	1.92 to 6.91	< 0.0001	2.63	1.37 to 5.04	0.004
Gastrointestinal disease	2.19	1.20 to 3.98	0.010	1.81	0.99 to 3.30	0.0534
Renal disease	1.93	0.70 to 5.28	0.20
Characteristics at follow-up
DAS28 (per unit increase)	1.24	1.02 to 1.50	0.034
DAS28
< 3.2	Referent
3.2 to 5.1	1.28	0.54 to 3.06	0.58
> 5.1	2.00	0.82 to 4.86	0.13
Ever exposed to
Conventional DMARDs only	Referent			Referent
Anti-TNF agents	0.61	0.39 to 0.97	0.039	0.70	0.44 to 1.12	0.133
Anakinra	1.16	0.47 to 2.89	0.75	1.39	0.56 to 3.48	0.480