Table 3.
Relation between compartment specific resolution compared with persistence of bone marrow lesions and change in knee cartilage (n = 37)
| Univariate analysis regression coefficient/odds ratio (95% CI) | P value | Multivariate analysis regression coefficient/odds ratio (95% CI)* |
P value | |
|---|---|---|---|---|
| Medial compartment | ||||
| Annual change in cartilage volume | -28.70 (-58.11, 0.68) | 0.05 | -35.90 (-65.00, -6.82)1 | 0.02 |
| Cartilage defects progress vs no change | 0.23 (0.05, 1.08) | 0.06 | 0.20 (0.04, 1.09)2 | 0.06 |
| Lateral compartment | ||||
| Annual change in cartilage volume | 24.70 (-18.88, 68.37) | 0.26 | 23.41 (-23.13, 70)1 | 0.31 |
| Cartilage defects progress vs no change | 1.08 (0.24, 4.90) | 0.92 | 1.08 (0.22, 5.39)2 | 0.92 |
1 Annual change in tibial cartilage volume if a bone marrow lesion (BML) resolved vs persisted after adjusting for age, gender, body mass index (BMI) and respective baseline tibial plateau area
2 Odds ratio for cartilage defects to progress if a BML resolved vs persisted after adjusting for age, gender, BMI and baseline cartilage volume
CI = confidence interval.