Figure 3.

Effects of pentosan polysulfate, hyaluronan, dextran sulfate and heparin on mesenchymal precursor cell proteoglycan biosynthesis. Bar graphs showing the concentration-dependent effects of (a) pentosan polysulfate (PPS), (b) heparin, (c) hyaluronan (HA) and (d) dextran sulfate (DS) on prosteoglycan (PG) synthesis by mesenchymal precursor stem cells (MPCs) in micromass cultures for 5 days. Data (mean ± standard deviation) presented as percentage of control calculated from the sulfated glycosaminoglycan (³⁵S-GAG) Decays Per Minute/μg DNA values at each drug concentration (n = 3). ^‡P < 0.05, *P < 0.01; **P < 0.001; ***P < 0.0001 relative to control values.