Table 3.

Percentage of plasma protein binding of S-4 and standard drugs

Compound	Resulta	Reported value
Ranitidine HCl	14.84 ± 1.21	10-19
Caffeine	40.66 ± 0.31	29-43
Methotrexate	50.70 ± 0.36	35-57
Propranolol HCl	80.12 ± 0.61	80-93
Warfarin	98.21 ± 0.24	99
S-4	78.82 ± 0.13	-

^aResults are average of three experiments ± SEM S-4: 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide