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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Eur J Neurosci. 2009 Sep 24;30(7):1358–1369. doi: 10.1111/j.1460-9568.2009.06904.x

Figure 1. Microinjection of the D1-like dopamine receptor agonist SKF-81297 into the medial prefrontal cortex reinstated cocaine seeking in rats.

Figure 1

(A) Ventral tips of the microinjection cannulae, as indicated by the closed circles, targeted the dorsal mPFC. Numbers on the left side of each coronal section denote distance from bregma in the anteroposterior direction. The inset displays a representative coronal section stained with 0.1% cresyl violet and viewed under 4x magnification using a light microscope. The arrow indicates a microinfusion site within the dorsal mPFC. (B) Total number of responses (mean±S.E.M.) on the active and inactive levers during the reinstatement session following intra-mPFC administration of saline (n=7) or 1.0 μg SKF-81297 (n=9). The asterisk denotes a significant difference on active lever responding between 1.0 μg SKF-81297 and saline treatments (unpaired t-test, P<0.0004). (C) The time courses of active lever responses (mean±S.E.M.) for the data summarized in panel B.