Figure 2.

Cumulus expansion and uterine decidual response are intact in Bmpr1a cKO mice. Immature female mice were superovulated, and COCs were obtained from the ampulla of the oviduct 16–18 h after hCG. A, Normal cumulus expansion in a control female, in contrast to impaired expansion and to poor adherence of cumulus cells around the oocyte in Bmpr1b^−/− (inset); B, cumulus expansion in Bmpr1a cKO females is intact; C, Bmpr1a cKO mice have a decrease in spontaneous ovulation, as determined by the number of blastocysts recovered from the uterus 3.5 d after mating with WT males (*, P < 0.05); D–F, there is no difference in the response to artificial induction of decidualization in control (E) vs. Bmpr1a cKO mice (F). Scale bar (E and F), 5 mm.