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. 2010 Apr 9;24(6):1230–1239. doi: 10.1210/me.2009-0497

Figure 3.

Figure 3

Coculture with WT- but not DM-oocytes promotes EGFR signaling in WT OOX cumulus cells. A, Levels of Egfr mRNA expressed in WT, COCs, OOX cumulus cells (OOX), OOX cumulus cell cocultured with WT Oocytes (OOX+WT), or DM oocytes (OOX+DM), 20 h after culture. B, Western blot analysis of EGFR, p-SMAD2, and β-actin (ACTB) in the same experimental groups as stated in panel A 20 h after culture. C, Changes of the levels of p-MAPK3/1 in the same experimental groups as stated in panel A after the initial 20-h culture and then treated with or without (control) AREG for 30 min. Groups indicated with different letters are significantly different, P < 0.05.