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. 2010 Apr 14;151(6):2423–2432. doi: 10.1210/en.2010-0089

Figure 3.

Figure 3

DSS-induced colitis in mice raised on vitamin D-sufficient and vitamin D-deficient diets. Eight-week-old mice raised on vitamin D-sufficient (normal) or vitamin D-deficient (D-deficient) diets were exposed to either regular tap water (C) or water + DSS. A, Animal health as determined by clinical scores. B, Histological scoring of colitis using colonic tissue sections. C–F, Example H&E staining for vitamin D-sufficient mice receiving tap water (control) (C) and vitamin D-sufficient mice receiving water with 2.5% DSS (control + DSS) (D). Arrow indicates immune infiltrate, double-lined arrow indicates loss of colonic epithelial morphology. E, Vitamin D-deficient mice receiving tap water (D-deficient). F, Vitamin D-deficient mice receiving water with 2.5% DSS (D-deficient + DSS). Values are means ± sem (n = 8). ***, Statistically different from corresponding vitamin D-sufficient mice (normal diet), P < 0.001; **, P < 0.01.