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. 2010 Jun 15;137(12):1981–1990. doi: 10.1242/dev.048439

Fig. 2.

Fig. 2.

Ovo1 is required for the migration of NC-derived pigment precursors. Dorsal views, anterior to the left. (A,C,E,G,I) Controls; (B,D,F,H,J) Ovo1 morphants. Embryos were processed by wholemount in situ hybridization for expression of sox10 (A,B), mitfa (C,D), gch (E,F), dlx2 (G,H) and foxd3 (I,J). NC cells migrate in bilateral streams in control embryos (A), but aggregate in the dorsal midline of Ovo1 morphants (B, arrow). Pigment precursors, which express mitfa and gch at 28 hpf, form ectopic clumps in the dorsal midline in Ovo1 morphants (D,F arrows) when compared with wild-type controls (C,E). However, skeletogenic and glial precursors, which express dlx2 and foxd3 at 24 hpf, respectively, do not form clumps in the midline in Ovo1 morphants (G-J). mbh, midbrain-hindbrain boundary; ot, otic vesicle; pa, pharyngeal arches.