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Delay of the ureteric bud branching in ICAT−/− mice. (A, B) Whole mount immunostaining for cytokeratin showing ureteric bud branching at E12.5. A: ICAT+/− kidney. A ureteric bud normally branches making 7 tips. B: ICAT−/− kidney. T-shaped ureteric bud after first branching with abnormally dilated tips. An arrow indicates Wolffian duct. Bar=200 µm.
