Fig. 1.

Effect of G6-31 (Anti-VEGF-A antibody) on E2 induced pituitary PRLoma in female F344 rats. E2 group: treatment protocol for E2-induced PRLoma, at seven-week of age female rats were given E2 (i.m., once weekly) for 13 wks. E2+G6-31 group: In the same manner as the E2 group and during the last 3 wks of E2 dosing, simultaneous use of G6-31 (i.v., once weekly) for 3 wks. Control group: Animals were treated with sesame oil as with E2 and saline with G6-31. Details are provided in Materials and Methods.