Table 3.
Laboratory Study Results Expressed as Median (Minimum, Maximum) Values
| Variable | Placebo (n = 26) | AdoMet (n = 26) | p |
|---|---|---|---|
| Hcy, μmol/L | |||
| Baseline | 7.5 (4.9, 10.5) | 8.3 (4.5, 13.1) | 0.18 |
| Week 2 | 6.9 (5.5, 9.8) | 8.8 (4.9, 12.4) | 0.26 |
| Week 4 | 7.5 (5.6, 10.5) | 8.2 (4.4, 12.2) | 0.32 |
| Baseline – week 2 | 0.0 (−2.3, 2.1) | 0.1 (−2.5, 3.3) | 0.94 |
| Baseline – week 4 | 0.0 (−2.3, 2.1) | 0.0 (−2.0, 2.9) | 0.53 |
| (Baseline – week 2)/baseline × 100% | 0.5 (−30.7, 23.3) | 1.3 (−40.4, 29.2) | 0.82 |
| (Baseline – week 4)/baseline × 100% | 0.0 (−30.7, 21.4) | 0.0 (−28.2, 23.4) | 0.39 |
| ALT, IU/L | |||
| Baseline | 21.0 (13.0, 143.0) | 22.0 (14.0, 45.0) | 0.91 |
| Week 2 | 20.5 (10.0, 143.0) | 25.0 (0.0, 44.0) | 0.29 |
| Week 4 | 23.0 (10.0, 143.0) | 23.5 (0.0, 47.0) | 0.76 |
| Baseline – week 2 | 1.0 (−20.0, 12.0) | −1.0 (−23.0, 17.0) | 0.03 |
| Baseline – week 4 | 0.0 (−8.0, 13.0) | 0.0 (−13.0, 16.0) | 0.54 |
| (Baseline – week 2)/baseline × 100% | 6.1 (−37.0, 33.3) | −3.9 (−109.5, 100.0) | 0.03 |
| (Baseline – week 4)/baseline × 100% | 0.0 (−38.1, 27.3) | 0.0 (−42.9, 100.0) | 0.62 |
| HsCRP, mg/dL | |||
| Baseline | 0.1 (0.0, 0.5) | 0.0 (0.0, 0.9) | 0.20 |
| Week 4 | 0.1 (0.0, 0.6) | 0.1 (0.0, 1.2) | 0.78 |
| Baseline – week 4 | 0.0 (−0.3, 0.2) | 0.0 (−1.1, 0.7) | 0.69 |
| (Baseline – week 4)/baseline × 100% | 0.0 (−157.0, 85.8) | 0.0 (−4122.0, 75.4) | 0.74 |
| Total cholesterol, mg/dL | |||
| Baseline | 185.5 (98.0, 267.0) | 182.5 (111.0, 238.0) | 0.99 |
| Week 4 | 198.5 (108.0, 267.0) | 181.0 (121.0, 234.0) | 0.20 |
| Baseline – week 4 | 0.0 (−64.0, 38.0) | 2.5 (−32.0, 43.0) | 0.04 |
| (Baseline – week 4)/baseline × 100% | 0.0 (−65.3, 26.0) | 1.3 (−17.6, 24.2) | 0.05 |
| HDL, mg/dL | |||
| Baseline | 52.5 (26.0, 75.0) | 51.0 (35.0, 112.0) | 0.58 |
| Week 4 | 55.5 (30.0, 73.0) | 47.5 (26.0, 109.0) | 0.76 |
| Baseline – week 4 | −0.5 (−13.0, 18.0) | 1.5 (−8.0, 18.0) | 0.09 |
| (Baseline – week 4)/baseline × 100% | −0.8 (−50.0, 32.1) | 2.4 (−17.5, 29.5) | 0.12 |
| Triglycerides, mg/dL | |||
| Baseline | 102.5 (42.0, 161.0) | 89.5 (46.0, 143.0) | 0.71 |
| Week 4 | 104.5 (39.0, 217.0) | 88.5 (38.0, 168.0) | 0.28 |
| Baseline – week 4 | −0.5 (−124.0, 68.0) | 1.0 (−32.0, 31.0) | 0.37 |
| (Baseline – week 4)/baseline × 100% | −0.5 (−133.3, 56.2) | 0.8 (−38.9, 36.7) | 0.33 |
p-values are Wilcoxon rank sum values.
AdoMet, S-adenosyl-l-methionine; ALT, alanine aminotransferase; Hcy, homocysteine; HDL, high-density lipoprotein; hsCRP, high-sensitivity C-reactive protein.