TABLE 3. Estimated Occupancy of D2/D3 Receptors Measured as AMPT-Induced Change in [11C]Raclopride Nondisplaceable Binding Potential.
| Striatal Subdivision | Increase in Nondisplaceable Binding Potential (%) | ||||
|---|---|---|---|---|---|
| Healthy Comparison Subjects (N=15) | Cocaine-Dependent Subjects (N=15) | Unpaired t test (p) | |||
| Mean | SD | Mean | SD | ||
| Ventral striatum | 10.6 | 6.5 | 3.4 | 7.4 | 0.007 |
| Precommissural dorsal caudate | 9.8 | 4.7 | 4.0 | 9.7 | 0.04 |
| Precommissural dorsal putamen | 10.5 | 4.8 | 4.7 | 7.6 | 0.02 |
| Postcommissural caudate | 12.2 | 9.4 | 9.0 | 10.3 | 0.43 |
| Postcommissural putamen | 12.3 | 5.4 | 6.7 | 6.1 | 0.01 |
| Striatum | 11.1 | 4.4 | 5.7 | 5.9 | 0.009 |