| Wilson et al. (13) |
Striatum |
Average use: 9.25 mg/kg in divided doses for at least 28 days (self-administered) |
| Akimoto et al. (14) |
Striatum |
20 mg/kg per day for 14 days (investigator-administered) |
| Segal and Kuczenski (15) |
Caudate, nucleus accumbens |
10 mg/kg per day for 4 days (investigator-administered) |
| Kalivas and Duffy (16) |
Striatum |
15 mg/kg per day for 4 days (investigator-administered) |
| Kalivas and Duffy (17) |
Nucleus accumbens |
15 or 30 mg/kg per day for 7 days (investigator-administered) |
| Parsons et al. (18) |
Nucleus accumbens |
20 mg/kg per day for 10 days (investigator-administered) |
| Chefer and Shippenberg (19) |
Nucleus accumbens |
20 mg/kg per day for 5 days (investigator-administered) |
| Zapata et al. (20) |
Nucleus accumbens |
0.5 mg/kg infusion for 90 minutes per 5 days (yoked- and self-administered) |
| Zhang et al. (21) |
Nucleus accumbens, caudate |
10 mg/kg per day for 7 days (investigator-administered) |
| Wilson et al. (22) |
Nucleus accumbens |
Average use: 90 mg/kg in divided doses for at least 21 days (self-administered) |
| Pettit et al. (23) |
Nucleus accumbens |
10 mg/kg per day for 5 days; 20 mg/kg per day for 25 days (investigator-administered) |
| Mateo et al. (24) |
Nucleus accumbens |
Following a fixed ratio schedule for 5 days; four discrete trials; 24 hours/day for 10 days (self-administered; average cocaine use: 750–800 mg/kg in 10 days) |
| Gerrits et al. (25) |
Nucleus accumbens |
30 μg infusion per 3 hours or maximum of 60 infusions per 5 days (self-administered) |
| Maisonnueve et al. (26) |
Striatum (ventral and dorsal) |
3 × 10–15 mg/kg for 13 days (investigator-administered) |
| Weiss et al. (27) |
Nucleus accumbens |
Unlimited access intravenous doses (self-administered) |
| Rossetti et al. (28) |
Ventral striatum |
15 mg/kg per 2 days for 15 days (investigator-administered) |
| Robertson et al. (29) |
Ventral striatum |
30 mg/kg per day for 18 days (investigator-administered) |
