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. Author manuscript; available in PMC: 2010 May 25.
Published in final edited form as: Cancer Chemother Pharmacol. 2008 Jun 28;63(4):681–689. doi: 10.1007/s00280-008-0785-8

Fig.1.

Fig.1

Effect of CDDO-Me on IL-6 secretion in OVCAR8TR and SKOV-3TR. IL-6 levels were measured using IL-6 ELISA on supernatants obtained from cultures of OVCAR8TR and SKOV-3TR cells treated with CDDO-Me in both a time- and dose-dependent manner. Results are mean ± SD of 3 independent experiments. A and C: CDDO-Me inhibits IL-6 protein synthesis in a dose-dependent manner. ELISA analysis of IL-6 levels isolated from OVCAR8TR (A) SKOV-3TR(C) that were cultured for 96 h in the presence of various concentrations of CDDO-Me as indicated. B and D: CDDO-Me inhibits IL-6 protein synthesis in a time-dependent manner. ELISA analysis of IL-6 levels isolated from OVCAR8TR (B) SKOV-3TR (D) that were cultured for the time indicated (in hours) in the presence of 0.3 μM of CDDO-Me.