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. Author manuscript; available in PMC: 2010 May 25.
Published in final edited form as: Cancer Chemother Pharmacol. 2008 Jun 28;63(4):681–689. doi: 10.1007/s00280-008-0785-8

Fig. 3.

Fig. 3

CDDO-Me inhibits Stat3 phosphorylation in paclitaxel-resistant ovarian cancer OVCAR8 TR cells. The OVCAR8 TR cells were treated with CDDO-Me as indicated and then total protein was harvested and 25 μg of cellular proteins were subjected to immunoblotting with specific antibodies as indicated. A. CDDO-Me reduces pStat3 levels OVCAR8TR cells as time dependent manner. OVCAR8TR cells were cultured for the time indicated (in hours) in the presence of 1 μM or 10 μM of CDDO-Me. B. CDDO-Me reduces pStat3 levels OVCAR8TR cells as dose dependent manner. OVCAR8TR cells were cultured for 24 h in the presence of various concentrations of CDDO-Me as indicated.