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. Author manuscript; available in PMC: 2010 May 25.
Published in final edited form as: Cancer Chemother Pharmacol. 2008 Jun 28;63(4):681–689. doi: 10.1007/s00280-008-0785-8

Fig. 4.

Fig. 4

CDDO-Me down-regulated Stat3 targeted anti-apoptotic proteins and induces apoptosis in cancer cells. OVCAR8TR was treated with CDDO-Me in time (A) or dose (B) dependent manner. Total cellular proteins were subjected to immunoblotting with specific antibodies to PARP, MCL-1, Bcl-2, Bcl-XL, surviving and β-actin as described in “Materials and Methods”. A: CDDO-Me reduces anti-apoptotic proteins in OVCAR8TR cells as time dependent manner. OVCAR8TR cells were cultured for the time indicated (in hours) in the presence of 1 μM or 10 μM of CDDO-Me. B: CDDO-Me reduces antiapoptotic proteins in OVCAR8TR cells as dose dependent manner. OVCAR8TR cells were cultured for 24 h in the presence of various concentrations of CDDO-Me as indicated.